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2019 Vol.14 No.6
Published 2019-12-25

Invited paper
Original Article
Case Analysis
Review
) [HTML 1KB] [PDF 315KB] ( 416 )
326 ZHANG Yi, ZHANG Haocheng
Advances in research on the pathogenesis of plague
The plague is a zoonotic disease caused by Yersinia pestis (Y. pestis). This bacterium Y. pestis has caused three deadly pandemic plague worldwide. Considering of expanding natural foci and frequent population turnover, prevention and control of plague is still grim. In this review, we mainly summarize the research progress on the virulence factors of Y. pestis, the mechanism of invasion, the intracellular replication and the dissemination mechanism in the host.
2019 Vol. 14 (6): 326-332 [Abstract] ( 54 ) [HTML 1KB] [PDF 613KB] ( 802 )
333 YANG Qingluan, WENG Taoping, LI Yang
The epidemiology of plague
Plague is a severe infectious disease caused by Yersinia pestis (Y. pestis), which seriously endangers human health. This article introduces the general characteristics and biological characteristics of Y. pestis, the pathogen of plague, and then summarizes the status of the plague situation at home and abroad. At present, the global epidemic trend of plague has entered a new active period. The World Health Organization has listed plague as one of the acute infectious diseases that have re-emerged in the past 20 years. The current global epidemic area is mainly distributed in Africa, Asia and South America. Similarly, the human plague in China has been in a clear upward trend since the 1980s. The epidemic has gradually declined in the past 10 years, but the situation is still difficult.
2019 Vol. 14 (6): 333-337 [Abstract] ( 56 ) [HTML 1KB] [PDF 571KB] ( 677 )
 
Original Article
338 XU Shuibao,YANG Siyu,WENG Shanshan,CHEN Chen,CHEN Shu,ZHANG Wenhong,JIN Jialin
Distribution of serotypes and virμlence genes of hypervirμlent Klebsiella pneumonia and exploring molecular markers
In order to investigate the distribution of serotypes and virulence genes of hypervirulent Klebsiella pneumoniae (HVKP) and to explore molecular markers, this study collected Klebsiella pneumoniae strains and divided into invasive syndrome KP group and bloodstream infection KP group.The results showed that the positive rate of serotype K1 in the invasive syndrome KP group was 60%, which was significantly higher than that in the bloodstream infection KP group. The rate of uge was the highest, followed by fimH. Overall, the positive rate of invasive syndrome KP virulence gene distribution was higher than that of bloodstream infection KP, especially rmpA2,magA, fimH,aero,iutA,kfuBC.According to the Yoden index, the diagnostic efficacy of these molecular markers was ranked from high to low: iutA>kfuBC> magA(K1)>aero>fimH>rmpA2. Multivariate logistic regression analysis showed that rmpA2, magA, fimH, aero, iutA and kfuBC could be used as molecular markers of HVKP, especially iutA, but lack 100% specific molecular markers, and further exploration is needed.
2019 Vol. 14 (6): 338-344 [Abstract] ( 58 ) [HTML 1KB] [PDF 572KB] ( 642 )
345 LI Chunyan, YANG Wenwei, WANG Keke, JIANG Liangzhi
Effect of infection control and antimicrobial management intervention on orthopedic surgery site infection
To evaluate the impact of infection control and antibacterial drug management interventions on surgical site infection (SSI) in the orthopedics of our hospital, the clinical cases from 2013 to 2018 of orthopedic in Yangpu District Central Hospital were subjected into this study. The patients were divided into pre-intervention group (2013-2014), after intervention group (2015-2017) and intensive intervention group (2018). Then the SSI of orthopedic was studied and the effect of intervention was evaluated. The SSI in orthopedic surgical patients decreased from 1.58% to 0.61% (P<0.05) after the implementation of infection control and antibacterial drug management interventions. The reasonable variety rates of antibiotics of type I and II incision before, after and intensive intervention were 54.83%, 79.82% and 99.04%, respectively. And the reasonable timing rates were 51.99%, 78.53% and 89.97%, respectively. The reasonable duration rates were 52.98%, 82.19% and 91.97%, respectively. The results showed that the incidence of SSI decreased significantly after the implementation of infection control and antimicrobial management intervention. The results had shown that the variety, the timing and duration of antibiotics were obviously improved (P<0.05). The average length of hospital stay was significantly reduced and the average costs of antibacterial drugs in total hospitalization costs decreased significantly (P<0.05). It is shown that long-term continuous comprehensive infection control and antibacterial drug management intervention can effectively reduce the incidence of infection in orthopedic surgery patients.
2019 Vol. 14 (6): 345-351 [Abstract] ( 46 ) [HTML 1KB] [PDF 734KB] ( 449 )
352 HAN Da1, WANG Yucheng1, FENG Huiqin1, CHENG Lele2 YANG Xiaotong1
Effects of polysaccharopeptide of Trametes versicolor on cancer-associated pathogenic enterobacteria in AOM/DSS-induced colorectal cancer mouse model
To investigate the effects of polysaccharopeptide (PSP) of Trametes versicolor on colorectal cancer-associated pathogenic enterobacteria (CAPEB), male mice were randomly divided into three groups: wild type group, Model group and PSP group. The mice in Model and PSP group were intraperitoneally injected with azoxymethane (AOM) and administrated with three cycles of dextran sodium sulfate (DSS) in drinking water to induce colorectal cancer. Mice in the PSP group were administrated daily with PSP (650 mg/kg) by gavage for 13 weeks. Diseases active indexes (DAI) were scored during the three DSS cycles, and the relative abundances of bacteria in stool samples were determined by quantitative real-time polymerase chain reaction. The results showed that the DAI of the PSP group was significantly decreased in the first two rounds of DSS treatment (P<0.05, P<0.01) compared to the model group. The relative abundances of each potential CAPEB of the PSP group, in terms of P. anaerobius, A. muciniphila, B. fragilis and C. symbiosum, were all lower than those of the model group, and the abundance of the first three bacteria mentioned above was significantly decreased in the mid-term of the experiment (P<0.05, P<0.01, P<0.05). These results indicated that PSP could alleviate DSS-induced inflammation and down-regulate abundance of colorectal cancer-associated pathogenic enterobacteria in mice, suggesting that PSP may have a preventive effect on inflammation-associated colorectal cancer.
2019 Vol. 14 (6): 352-357 [Abstract] ( 52 ) [HTML 1KB] [PDF 1712KB] ( 451 )
 
Case Analysis
358 WANG Niuniu1,2, QIN Yanli1, WANG Xinyu1
Disseminated histoplasmosis diagnosed by mNGS in an immunocompetent individual: a case report
Histoplasmosis is a common endemic mycosis that is usually asymptomatic but occasionally results in severe illness. Histoplasmosis and its causative agent, Histoplasma capsulatum, are found worldwide and particularly in North and Central America. Disseminated histoplasmosis is a progressive extrapulmonary infection. The diagnosis of disseminated histoplasmosis should be suspected in patients with risk factors for disease (e. g.,immunosuppression or extremes of age and risk factors for exposure) in combination with clinical manifestations that are consistent with disseminated histoplasmosis. We reported a case of disseminated histoplasmosis in an immunocompetent individual. The case was subacute with rapid progress in the later stage. It was diagnosed by bone marrow smear and metagenomic next-generation sequencing (mNGS). The patient improved after treatment by Amphotericin B deoxycholate and itraconazole. With the increasing reports of disseminated histoplasmosis in China, the clinicians should give careful attention to the disease. The epidemiological status, clinical manifestations, diagnostic criteria and treatment principle of disseminated histoplasmosis were summarized in this paper.
2019 Vol. 14 (6): 358-362 [Abstract] ( 42 ) [HTML 1KB] [PDF 11709KB] ( 299 )
 
Review
363 WU Chaoyi, ZHOU Liting, HUANG Rui, WU Shuyan
Advances in the study of bacterial infection and programmed host cell death mediated by Gasdermin family
Bacteria can grow and multiply inside the host after invasion, causing pathological changes. In order to inhibit the pathogenic process of bacteria, the host immune system produces anti-infective responses. The occurrence and development of infection depends on the interaction between pathogenicity of bacteria and antimicrobial immunity of host. Programmed cell death (PCD) is usually involved in the confrontation between bacteria and host cells in bacteria-induced infectious diseases. It has been discovered that members of the Gasdermin (GSDM) family such as GSDMD and GSDME participate in the PCD process and play an important role in it. Tracking the research progress can help us to deal with the threat posed by bacterial infection.
2019 Vol. 14 (6): 363-370 [Abstract] ( 53 ) [HTML 1KB] [PDF 1036KB] ( 409 )
371 KANG Yaoxia1,XIE Yingbo1,LUO Wenbo2
Research advances of biological features in Brucella phages
The phage biotyped method plays an irreplaceable role in the identification and subtyping of Brucella. This article reviews the growth characteristic and host specificity of Brucella phages.
2019 Vol. 14 (6): 371-374 [Abstract] ( 51 ) [HTML 1KB] [PDF 380KB] ( 287 )
375 JIANG Yi-wen1,2, WANG Xuan-yi1, ZHU Wei3, QU Di1
The current vaccination program and related safety problem in China
Vaccination plays an important role in the control and prevention of infectious diseases. In this review, we discuss the vaccines immunization program of China (mandatory vaccines and the alternative ones). Immunization strategy may differ according to the types of vaccines for potential adverse effects. Vaccine immunization-related safety incidents and lessons learned have also been discussed.
2019 Vol. 14 (6): 375-386 [Abstract] ( 65 ) [HTML 1KB] [PDF 1336KB] ( 664 )
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