Abstract:Risk factors,clinical featuresand drug resistance analysis of nosocomial infection caused by Elizabethameningealis in elderly patients Zhang Dan,SunGuiqin 1.School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China 2. Shaoxing People’s Hospital, Shaoxing Hospital, Zhejiang University, Shaoxing, Zhejiang 312000, China Corresponding Author: Sun Guiqin, Email:sunguiqin2001 @163.com ABSTRACT: OBJECTIVE To investigate the susceptible factors, clinical features and drug resistance of Elisabeth meningisepticum (E.M) infection in elderly patients, so as to providereference for clinical scientific and effective treatment. METHODS Analysis of 27 strains of EM infected patients aged over 60 years who were isolated from Shaoxing People's Hospital from January 2018 to January 2023 was carried out using VITEK-2 automatic microbial identification and drug sensitivity analyzer for bacterial identification and drug sensitivity tests, and statistical analysis of the clinical characteristics and drug resistance of the bacteria. RESULTS The main infection of EM is the long hospitalization time, with 66.7% of patients staying in hospital for ≥ 28 days; There are serious underlying diseases, including COPD patients (25.9%), pulmonary infections (18.5%), and malignant tumors (22.2%); Elderly patients who have been using broad-spectrum antibacterial drugs for a long time and have undergone invasive procedures. The main type of specimen was sputum (87.8%), followed by urine (9.1%); The patients mainly came from the Department of Critical Care (74.1%), followed by the Department of Radiotherapy (7.4%); EM exhibits high resistance to a variety of broad-spectrum antibacterial drugs, but is 100% sensitive to doxycycline. The resistance to cefoperazone/tazobactam, piperacillin/tazobactam, cotrimoxazole, and levofloxacin is<30%. CONCLUSION The presence of serious underlying diseases and prolonged hospitalization, combined use of broad-spectrum antibiotics, and multiple invasive diagnoses and treatments are risk factors for elderly patients with EM infection. The phenomenon of multiple drug resistance in EM is serious. Rational use of antibiotics, active treatment of primary diseases, minimizing invasive procedures, reducing hospital stay, and strengthening medical environmental management are conducive to the treatment and prevention of EM.
张丹 孙桂芹. 脑膜败血伊丽莎白菌致老年患者医院感染的危险因素、临床特征及耐药性分析[J]. 微生物与感染, 2023, 18(5): 278-283.
Dan ZHANG. Risk factors,clinical featuresand drug resistance analysis of nosocomial infection caused by Elizabethameningealis in elderly patients. JOURNAL OF MICROBES AND INFECTIONS, 2023, 18(5): 278-283.