Abstract:The incidence of invasive fungal infections has increased year by year. However, the current antifungal drugs are scarce and the development of new drugs is relatively slow. Therefore, it is urgent to develop new antifungal drugs. Natural products have the characteristics of wide sources and low side effects. They are one of the sources of antifungal drugs. A large number of studies have proved that many compounds isolated from plants and traditional Chinese medicine have antifungal activities, and the antifungal mechanisms are different. This review discusses the latest progress in development of natural products antifungal drugs, investigates the natural products with potential antifungal activity, and puts forward the prospect of the development of new antifungal candidate drugs.
Butts A, Krysan DJ.Antifungal drug discovery: something old and something new[J].PLoS Pathog, 2012, 8(9):1-3
[2]
Negri M, Salci TP, Shinobu-Mesquita CS, Capoci IR, Svidzinski TI, Kioshima ES.Early state research on antifungal natural products[J].Molecules, 2014, 19(3):2925-2956
[3]
Cardoso J, Nakayama DG, Sousa E, Pinto E.Marine-Derived Compounds and Prospects for Their Antifungal Application[J].Molecules, 2020, 25:1-27
[4]
Casadevall A.Immunity to Invasive Fungal Diseases[J].Annu Rev Immunol, 2022, 40:-
[5]
Van Daele R, Spriet I, Wauters J, Maertens J, Mercier T, Van Hecke S, Bruggemann R.Antifungal drugs: What brings the future?[J].Med Mycol, 2019, 57(Supplement_3):S328-S343
[6]
Perlin DS, Rautemaa-Richardson R, Alastruey-Izquierdo A.The global problem of antifungal resistance: prevalence,mechanisms,and management[J].Lancet Infect Dis, 2017, 17(12):e383-e392
[7]
Fisher MC, Hawkins NJ, Sanglard D, Gurr SJ.Worldwide emergence of resistance to antifungal drugs challenges human health and food security[J].Science, 2018, 360(6390):739-742
[8]
Wiederhold NP.Antifungal resistance: current trends and future strategies to combat[J].Infect Drug Resist, 2017, 10:249-259
[9]
Lockhart SR, Etienne KA, Vallabhaneni S, Farooqi J, Chowdhary A, Govender NP, Colombo AL, Calvo B, Cuomo CA, Desjardins CA, Berkow EL, Castanheira M, Magobo RE, Jabeen K, Asghar RJ, Meis JF, Jackson B, Chiller T, Litvintseva AP.Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses[J].Clin Infect Dis, 2017, 64(2):134-140
[10]
Liu X, Ma Z, Zhang J, Yang L.Antifungal Compounds against Candida Infections from Traditional Chinese Medicine[J].Biomed Res Int, 2017, :-
[11]
Roemer T, Xu D, Singh SB, Parish CA, Harris G, Wang H, Davies JE, Bills GF.Confronting the challenges of natural product-based antifungal discovery[J].Chem Biol, 2011, 18(2):148-164
[12]
Moloney MG.Natural Products as a Source for Novel Antibiotics[J].Trends Pharmacol Sci, 2016, 37(8):689-701
[13]
Hwang B, Cho J, Hwang IS, Jin HG, Woo ER, Lee DG.Antifungal activity of lariciresinol derived from Sambucus williamsii and their membrane-active mechanisms in Candida albicans[J].Biochem Biophys Res Commun, 2011, 410(3):489-493
[14]
Hwang B, Lee J, Liu QH, Woo ER, Lee DG.Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii[J].Molecules, 2010, 15(5):3507-3516
[15]
Sun LM, Liao K, Liang S, Yu PH, Wang DY.Synergistic activity of magnolol with azoles and its possible antifungal mechanism against Candida albicans[J].J Appl Microbiol, 2015, 118(4):826-838
[16]
Samber N, Khan A, Varma A, Manzoor N.Synergistic anti-candidal activity and mode of action of Mentha piperita essential oil and its major components[J].Pharm Biol, 2015, 53(10):1496-1504
[17]
Khan A, Ahmad A, Ahmad Khan L, Padoa CJ, van Vuuren S, Manzoor N.Effect of two monoterpene phenols on antioxidant defense system in Candida albicans[J].Microb Pathog, 2015, 80:50-56
[18]
Childers DS, Avelar GM, Bain JM, Larcombe DE, Pradhan A, Budge S, Heaney H, Brown AJP.Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance[J].Curr Top Microbiol Immunol, 2020, 425:297-330
[19]
Sultan T, Ali SA.Psoralea corylifolia extracts stimulate cholinergic-like psoralen receptors of tadpole-tail melanophores,leading to skin darkening[J].J Recept Signal Transduct Res, 2011, 31(1):39-44
[20]
Wijnants S, Vreys J, Van Dijck P.Interesting antifungal drug targets in the central metabolism of Candida albicans[J].Trends Pharmacol Sci, 2022, 43(1):69-79
[21]
Shao J, Cui Y, Zhang M, Wang T, Wu D, Wang C.Synergistic in vitro activity of sodium houttuyfonate with fluconazole against clinical Candida albicans strains under planktonic growing conditions[J].Pharm Biol, 2017, 55(1):355-359
[22]
Mahmoudvand H, Ayatollahi Mousavi SA, Sepahvand A, Sharififar F, Ezatpour B, Gorohi F, Saedi Dezaki E, Jahanbakhsh S.Antifungal, Antileishmanial, and Cytotoxicity Activities of Various Extracts of Berberis vulgaris (Berberidaceae) and Its Active Principle Berberine[J].ISRN Pharmacol, 2014, :-
Zhu SL, Yan L, Zhang YX, Jiang ZH, Gao PH, Qiu Y, Wang L, Zhao MZ, Ni TJ, Cai Z, Tian SJ, Zang CX, Zhang DZ, Jiang YY.Berberine inhibits fluphenazine-induced up-regulation of CDR1 in Candida albicans[J].Biol Pharm Bull, 2014, 37(2):268-273
[25]
Khan N, Shreaz S, Bhatia R, Ahmad SI, Muralidhar S, Manzoor N, Khan LA.Anticandidal activity of curcumin and methyl cinnamaldehyde[J].Fitoterapia, 2012, 83(3):434-440
[26]
Sharma M, Manoharlal R, Negi AS, Prasad R.Synergistic anticandidal activity of pure polyphenol curcumin I in combination with azoles and polyenes generates reactive oxygen species leading to apoptosis[J].FEMS Yeast Res, 2010, 10(5):570-578
[27]
Sharma M, Manoharlal R, Puri N, Prasad R.Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans[J].Biosci Rep, 2010, 30(6):391-404
[28]
Yun DG, Lee DG.Silibinin triggers yeast apoptosis related to mitochondrial Ca(2+) influx in Candida albicans[J].Int J Biochem Cell Biol, 2016, 80:1-9
[29]
Siscar-Lewin S, Hube B, Brunke S.Emergence and evolution of virulence in human pathogenic fungi[J].Trends in Microbiology, 2022, :-
[30]
Sun L, Liao K, Wang D.Effects of magnolol and honokiol on adhesion,yeast-hyphal transition,and formation of biofilm by Candida albicans[J].PLoS One, 2015, 10(2):e0117695-
[31]
Lohse MB, Gulati M, Johnson AD, Nobile CJ.Development and regulation of single- and multi-species Candida albicans biofilms[J].Nat Rev Microbiol, 2018, 16(1):19-31
[32]
Evensen NA, Braun PC.The effects of tea polyphenols on Candida albicans: inhibition of biofilm formation and proteasome inactivation[J].Can J Microbiol, 2009, 55(9):1033-1039
[33]
Sangetha S, Zuraini Z, Suryani S, Sasidharan S.In situ TEM and SEM studies on the antimicrobial activity and prevention of Candida albicans biofilm by Cassia spectabilis extract[J].Micron, 2009, 40(4):439-443
[34]
Furletti VF, Teixeira IP, Obando-Pereda G, Mardegan RC, Sartoratto A, Figueira GM, Duarte RM, Rehder VL, Duarte MC, Hofling JF.Action of Coriandrum sativum L. Essential Oil upon Oral Candida albicans Biofilm Formation[J].Evid Based Complement Alternat Med, 2011, :-
[35]
Thaweboon S, Thaweboon B.In vitro antimicrobial activity of Ocimum americanum Lessential oil against oral microorganisms[J].Southeast Asian J Trop Med Public Health, 2009, 40(5):1025-1033
[36]
Zida A, Bamba S, Yacouba A, Ouedraogo-Traore R, Guiguemde RT.Anti-Candida albicans natural products,sources of new antifungal drugs: A review[J].J Mycol Med, 2017, 27(1):1-19
[37]
Khan MS, Ahmad I.Antibiofilm activity of certain phytocompounds and their synergy with fluconazole against Candida albicans biofilms[J].J Antimicrob Chemother, 2012, 67(3):618-621
[38]
Xie Y, Liu X, Zhou P.In vitro Antifungal Effects of Berberine Against Candida spp. In Planktonic and Biofilm Conditions[J].Drug Des Devel Ther, 2020, 14:87-101
[39]
Seleem D, Benso B, Noguti J, Pardi V, Murata RM.In Vitro and In Vivo Antifungal Activity of Lichochalcone-A against Candida albicans Biofilms[J].PLoS One, 2016, 11(6):e0157188-
Vitale RG.Role of Antifungal Combinations in Difficult to Treat Candida Infections[J].J Fungi (Basel), 2021, 7:-
[42]
Bhattacharya R, Rolta R, Dev K, Sourirajan A.Synergistic potential of essential oils with antibiotics to combat fungal pathogens: Present status and future perspectives[J].Phytother Res, 2021, 35(11):6089-6100
[43]
Herman A, Herman AP.Herbal Products and Their Active Constituents Used Alone and in Combination with Antifungal Drugs against Drug-Resistant Candida sp[J].Antibiotics (Basel), 2021, 10:-
[44]
Liu J, Li Q, Wang C, Shao J, Wang T, Wu D, Ma K, Yan G, Yin D.Antifungal evaluation of traditional herbal monomers and their potential for inducing cell wall remodeling in Candida albicans and Candida auris[J].Biofouling, 2020, 36(3):319-331
[45]
Qian W, Yang M, Li X, Sun Z, Li Y, Wang X, Wang T.Anti-microbial and anti-biofilm activities of combined chelerythrine-sanguinarine and mode of action against Candida albicans and Cryptococcus neoformans in vitro[J].Colloids Surf B Biointerfaces, 2020, 191:-
[46]
Coleman JJ, Okoli I, Tegos GP, Holson EB, Wagner FF, Hamblin MR, Mylonakis E.Characterization of plant-derived saponin natural products against Candida albicans[J].ACS Chem Biol, 2010, 5(3):321-332
[47]
Sadeghi-Ghadi Z, Vaezi A, Ahangarkani F, Ilkit M, Ebrahimnejad P, Badali H.Potent in vitro activity of curcumin and quercetin co-encapsulated in nanovesicles without hyaluronan against Aspergillus and Candida isolates[J].J Mycol Med, 2020, 30(4):101014-
[48]
Janeczko M, Kochanowicz E.Silymarin, a Popular Dietary Supplement Shows Anti-Candida Activity[J].Antibiotics (Basel), 2019, (8):-
[49]
Kumar R, Subramani R, Aalbersberg W.Three bioactive sesquiterpene quinones from the Fijian marine sponge of the genus Hippospongia[J].Nat Prod Res, 2013, 27(16):1488-1491
[50]
Kalemba D, Kunicka A.Antibacterial and antifungal properties of essential oils[J].Curr Med Chem, 2003, 10(10):813-829
Silva RAD, Antonieti F, Roder D, Pedroso RDS.Essential Oils of Melaleuca, Citrus, Cupressus, and Litsea for the Management of Infections Caused by Candida Species: A Systematic Review[J].Pharmaceutics, 2021, 13:-
[54]
Tariq S, Wani S, Rasool W, Shafi K, Bhat MA, Prabhakar A, Shalla AH, Rather MA.A comprehensive review of the antibacterial, antifungal and antiviral potential of essential oils and their chemical constituents against drug-resistant microbial pathogens[J].Microb Pathog, 2019, 134:-
[55]
Brilhante RSN, Araujo GDS, Fonseca X, Guedes GMM, Aguiar L, Castelo-Branco D, Cordeiro RA, Sidrim JJC, Pereira Neto WA, Rocha MFG.Antifungal effect of anthraquinones against Cryptococcus neoformans: detection of synergism with amphotericin B[J].Med Mycol, 2020, :-
[56]
Janeczko M.Emodin Reduces the Activity of (1,3)-beta-D-glucan Synthase from Candida albicans and Does Not Interact with Caspofungin[J].Pol J Microbiol, 2018, 67(4):463-470
[57]
Kang K, Fong WP, Tsang PW.Novel antifungal activity of purpurin against Candida species in vitro[J].Med Mycol, 2010, 48(7):904-911
Behbehani J, Shreaz S, Irshad M, Karched M.The natural compound magnolol affects growth, biofilm formation, and ultrastructure of oral Candida isolates[J].Microb Pathog, 2017, 113:209-217
[60]
Bang KH, Kim YK, Min BS, Na MK, Rhee YH, Lee JP, Bae KH.Antifungal activity of magnolol and honokiol[J].Arch Pharm Res, 2000, 23(1):46-49
[61]
Saracino IM, Foschi C, Pavoni M, Spigarelli R, Valerii MC, Spisni E.Antifungal Activity of Natural Compounds vs. Candida spp.: A Mixture of Cinnamaldehyde and Eugenol Shows Promising In Vitro Results[J].Antibiotics, 2022, 11:-
[62]
Li Z, Yin H, Chen W, Jiang C, Hu J, Xue Y, Yao D, Peng Y, Hu X.Synergistic Effect of Pseudolaric Acid B with Fluconazole Against Resistant Isolates and Biofilm of Candida tropicalis[J].Infect Drug Resist, 2020, 13:2733-2743
Miranda-Cadena K, Marcos-Arias C, Mateo E, Aguirre-Urizar JM, Quindos G, Eraso E.In vitro activities of carvacrol, cinnamaldehyde and thymol against Candida biofilms[J].Biomed Pharmacother, 2021, 143:-
[65]
Teixeira APC, Nobrega RO, Lima EO, Araujo WO, Lima IO.Antifungal activity study of the monoterpene thymol against Cryptococcus neoformans[J].Nat Prod Res, 2020, 34(18):2630-2633
[66]
Iraji A, Yazdanpanah S, Alizadeh F, Mirzamohammadi S, Ghasemi Y, Pakshir K, Yang Y, Zomorodian K.Screening the antifungal activities of monoterpenes and their isomers against Candida species[J].J Appl Microbiol, 2020, 129(6):1541-1551
[67]
Hsu CC, Lai WL, Chuang KC, Lee MH, Tsai YC.The inhibitory activity of linalool against the filamentous growth and biofilm formation in Candida albicans[J].Med Mycol, 2013, 51(5):473-482
[68]
Ansari MA, Fatima Z, Hameed S.Anticandidal Effect and Mechanisms of Monoterpenoid,Perillyl Alcohol against Candida albicans[J].PLoS One, 2016, 11(9):e0162465-
[69]
da Silva DL, Magalhaes TF, Dos Santos JR, de Paula TP, Modolo LV, de Fatima A, Buzanello Martins CV, Santos DA, de Resende-Stoianoff MA.Curcumin enhances the activity of fluconazole against Cryptococcus gattii-induced cryptococcosis infection in mice[J].J Appl Microbiol, 2016, 120(1):41-48
[70]
Wang T, Shi G, Shao J, Wu D, Yan Y, Zhang M, Cui Y, Wang C.In vitro antifungal activity of baicalin against Candida albicans biofilms via apoptotic induction[J].Microb Pathog, 2015, 87:21-29
[71]
Lee H, Woo ER, Lee DG.Apigenin induces cell shrinkage in Candida albicans by membrane perturbation[J].FEMS Yeast Res, 2018, 18:-
[72]
Bhagya N, Chandrashekar KR.Tetrandrine--A molecule of wide bioactivity[J].Phytochemistry, 2016, 125:5-13
[73]
高磊.天然药物小檗碱抑制烟曲霉作用机制的研究 [D]. 吉林大学, 2012.
[74]
叶政苑.小檗碱抗新生隐球菌活性和作用机制研究 [D]. 西南大学, 2019.
[75]
Zoric N, Kosalec I, Tomic S, Bobnjaric I, Jug M, Vlainic T, Vlainic J.Membrane of Candida albicans as a target of berberine[J].BMC Complement Altern Med, 2017, 17(1):268-
[76]
Shao J, Wang T, Yan Y, Shi G, Cheng H, Wu D, Wang C.Matrine reduces yeast-to-hypha transition and resistance of a fluconazole-resistant strain of Candida albicans[J].J Appl Microbiol, 2014, 117(3):618-626
[77]
Li ZJ, Liu M, Dawuti G, Dou Q, Ma Y, Liu HG, Aibai S.Antifungal Activity of Gallic Acid In Vitro and In Vivo[J].Phytother Res, 2017, 31(7):1039-1045
[78]
Wu XZ, Chang WQ, Cheng AX, Sun LM, Lou HX.Plagiochin E,an antifungal active macrocyclic bis(bibenzyl),induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway[J].Biochim Biophys Acta, 2010, 1800(4):439-447
[79]
Mandras N, Roana J, Scalas D, Del Re S, Cavallo L, Ghisetti V, Tullio V.The Inhibition of Non-albicans Candida Species and Uncommon Yeast Pathogens by Selected Essential Oils and Their Major Compounds[J].Molecules, 2021, 26:-
[80]
Djeddi S, Djebile K, Hadjbourega G, Achour Z, Argyropoulou C, Skaltsa H.In vitro antimicrobial properties and chemical composition of Santolina chamaecyparissus essential oil from Algeria[J].Nat Prod Commun, 2012, 7(7):937-940
[81]
Pandey AK, Mishra AK, Mishra A.Antifungal and antioxidative potential of oil and extracts derived from leaves of Indian spice plant Cinnamomum tamala[J].Cell Mol Biol (Noisy-le-grand), 2012, 58(1):142-147
[82]
Freires Ide A, Murata RM, Furletti VF, Sartoratto A, Alencar SM, Figueira GM, de Oliveira Rodrigues JA, Duarte MC, Rosalen PL.Coriandrum sativum L(Coriander) essential oil: antifungal activity and mode of action on Candida spp.,and molecular targets affected in human whole-genome expression[J].PLoS One, 2014, 9(6):e99086-
[83]
Bozin B, Mimica-Dukic N, Samojlik I, Jovin E.Antimicrobial and antioxidant properties of rosemary and sage (Rosmarinus officinalis Land Salvia officinalis L.,Lamiaceae) essential oils[J].J Agric Food Chem, 2007, 55(19):7879-7885
[84]
Mageed MAAE, Mansour AF, El Massry KF, Ramadan MM, Shaheen MS, Shaaban H.Effect of microwaves on essential oils of coriander and cumin seeds and on their antioxidant and antimicrobial activities[J].Journal of Essential Oil Bearing Plants, 2012, 15(4):614-627
[85]
Joe MM, Jayachitra J, Vijayapriya M.Antimicrobial activity of some common spices against certain human pathogens[J].Journal of Medicinal Plants Research, 2009, 3(12):1134-1136
[86]
Ali NH, Faizi S, Kazmi SU.Antibacterial activity in spices and local medicinal plants against clinical isolates of Karachi,Pakistan[J].Pharm Biol, 2011, 49(8):833-839
[87]
Yakout SM, Abd-Alrahman SH, Mostafa A, Salem-Bekhit MM.Antimicrobial effect of seed ethanolic extract of coriander[J].J. Pure Appl. Microbiol, 2013, 7:459-463
[88]
Hussien J, Teshale C, Mohammed J.Assessment of the antimicrobial effects of some Ethiopian aromatic spice and herb hydrosols[J].Int J Pharmacol, 2011, 7(5):635-640
[89]
A?ao?lu S, Dostbil N, Alemdar S.Antimicrobial activity of some spices used in the meat industry[J].Bull Vet Inst Pulawy, 2007, 51:53-57
[90]
Gurnani N, Gupta M, Shrivastava R, Mehta D, Mehta BK.Effect of extraction methods on yield, phytochemical constituents, antibacterial and antifungal activity of Capsicum frutescens L [J].Indian Journal of Natural Products and Resources, 2016, 7:32-39
[91]
Khan H, Khan MA, Mahmood T, Choudhary MI.Antimicrobial activities of Gloriosa superba Linn (Colchicaceae) extracts[J].J Enzyme Inhib Med Chem, 2008, 23(6):855-859
[92]
Ceyhan N, Keskin D, Ugur A.Antimicrobial activities of different extracts of eight plant species from four different family against some pathogenic microoorganisms[J].J. Food Agric. Environ, 2012, 10:193-197